Recombinant CD63 antibody (full length)

Catalog No. ABIN6654892

The Rabbit Monoclonal anti-CD63 antibody is suitable to detect CD63 in samples from Human. It has been validated for FACS and IHC (p).

Quick Overview for Recombinant CD63 antibody (full length) (ABIN6654892)

Target: CD63

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD63 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: LAMP3-2990R

Product Details anti-CD63 Antibody

Binding Specificity: full length

Purpose: Recombinant CD63 Antibody / LAMP-3 (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogen: Recombinant human full-length protein was used as the immunogen for the recombinant CD63 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant CD63 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant CD63 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CD63

Target: CD63

Alternative Name: CD63

Background: This mAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63/LAMP-3. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63/LAMP-3 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. It is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP-3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.

UniProt: P08962