SETD8 antibody

Catalog No. ABIN6655982

Supplier Product No.: 100-401-v82

This anti-SETD8 antibody is a Rabbit Polyclonal antibody detecting SETD8 in WB. Suitable for Human.

Quick Overview for SETD8 antibody (ABIN6655982)

Target: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETD8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SETD8 Antibody

Supplier Product No.: 100-401-v82

Supplier: Rockland

Purpose: SETD8 Antibody

Cross-Reactivity (Details): Cross reactivity with SETD8 from species other than human and mouse not tested.

Purification: Anti-SETD8 Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Sterility: Sterile filtered

Immunogen: Anti-SETD8 Antibody was produced in rabbits by repeated immunizations of the full length human SETD8 protein containing a Flag-tagged N-terminus and a His-tagged C terminus.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1,000

Comment:

Anti-SETD8 Antibody has been tested by western blots. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 40 kDa in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: None

Stabilizer: None

Preservative: 0.05 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for SETD8

Target: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Alternative Name: SETD8

Background:

Synonyms: N-lysine methyltransferase SETD8, H4-K20-HMTase SETD8, Histone-lysine N-methyltransferse SETD8, Lysine N-methyltransferase 5A, PR/SET domain-containing protein 07, SET domain-containing protein 8, PR-Set7, PR/SET07

Background: SETD8 is a histone methyl transferase that specifically monomethylates 'Lys-20' of histone H4. This histone modification represents a specific tag for epigenetic transcriptional repression and is enriched during mitosis. SETD8 may also play a role in maintaining silet chromatin by preventing the acetylation of the H4 tail. Anti-SETD8 Antibody is ideal for research in Gene Expression, Epigenetics and Chromatin Remodeling.

Gene Name: SETD8

Gene ID: 387893

NCBI Accession: NP_065115

UniProt: Q9NQR1