SNCA antibody

Catalog No. ABIN6656439

Supplier Product No.: 500-301-e56

This Mouse Monoclonal antibody specifically detects SNCA in WB, ELISA, IF, FM and MA. It exhibits reactivity toward Human.

Quick Overview for SNCA antibody (ABIN6656439)

Target: SNCA (Synuclein, alpha (SNCA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SNCA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Fluorescence Microscopy (FM), Multiplex Assay (MA)

Clone: 2A7

Product Details anti-SNCA Antibody

Supplier Product No.: 500-301-e56

Supplier: Rockland

Purpose: Alpha Synuclein Antibody

Cross-Reactivity (Details): Anti-Alpha Synuclein Antibody is directed against human Alpha Synuclein protein.

Purification: The antibody was purified by protein G purification from tissue culture supernatant.

Immunogen: Anti-Alpha Synuclein Antibody was produced by repeated immunizations with full length human alpha synuclein expressed in E. coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA_Dilution: 1:10,000

IF_Microscopy_Dilution: 1:500

Western_Blot_Dilution: 1:1000

Comment:

Alpha Synuclein antibody is tested for use in Western Blotting and IF. Specific conditions should be optimized by the end user. Expect a band of approximately 15 kDa in size corresponding to the alpha synuclein proteins in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: Alpha Synuclein

Background:

Synonyms: mouse anti-Alpha Synuclein Antibody, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP

Background: Alpha Synuclein Antibody detects Alpha Synuclein protein. Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes. Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS). Anti-Alpha-synuclein antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: SNCA

Gene ID: 6622

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity