Retinoic Acid Receptor beta antibody (N-Term)

Catalog No. ABIN6657358

Supplier Product No.: 209-301-e26

The Mouse Monoclonal anti-Retinoic Acid Receptor beta antibody has been validated for WB. It is suitable to detect Retinoic Acid Receptor beta in samples from Human.

Quick Overview for Retinoic Acid Receptor beta antibody (N-Term) (ABIN6657358)

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoic Acid Receptor beta antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 336

Product Details anti-Retinoic Acid Receptor beta Antibody

Binding Specificity: N-Term

Supplier Product No.: 209-301-e26

Supplier: Rockland

Purpose: Retinoic Acid Receptor beta Antibody

Cross-Reactivity (Details): Retinoic Acid Receptor beta antibodies was Protein G purified from cell culture supernatant.

Purification: Anti-Retinoic Acid Receptor beta antibody detects Retinoic Acid Receptor beta.

Immunogen: Anti-Retinoic Acid Receptor beta was produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues from the N-terminal region of RAR beta.

Isotype: IgG1

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-Retinoic Acid Receptor beta antibody is tested for use in Western Blotting to detect a single band at approximately 48 kDa corresponding to expected molecular weight for RAR-β proteins in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for Retinoic Acid Receptor beta

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Alternative Name: Retinoic Acid Receptor beta

Background:

Synonyms: mouse anti-Retinoic Acid Receptor beta Antibody, mouse anti-RAR-beta antibody, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon

Background: Retinoic Acid Receptor beta antibody detects RAR beta. Retinoic Acid (RA, active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X receptors (RXRs) family (RXRα, β and γ) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

Gene Name: RARB

Gene ID: 5915

UniProt: P10826

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway