MDC1 antibody (N-Term)

Catalog No. ABIN6657611

Supplier Product No.: 200-301-g12

This anti-MDC1 antibody is a Mouse Monoclonal antibody detecting MDC1 in FM. Suitable for Mouse.

Quick Overview for MDC1 antibody (N-Term) (ABIN6657611)

Target: MDC1 (Mdc1 (MDC1))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MDC1 antibody is un-conjugated

Application: Fluorescence Microscopy (FM)

Clone: P2B11

Product Details anti-MDC1 Antibody

Binding Specificity: N-Term

Supplier Product No.: 200-301-g12

Supplier: Rockland

Purpose: Mdc1 Antibody

Cross-Reactivity (Details): A BLAST analysis was used to suggest cross-reactivity with MDC1 from Human, Mouse, Chimpanzee, and Bovine based on 100 % homology with the immunizing sequence.

Purification: Anti-MDC1 Antibody was purified by Protein G chromatography.

Sterility: Sterile filtered

Immunogen: MDC1 Antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to mouse MDC1 at and around the N-terminus region.

Isotype: IgG1

Application Details

Application Notes: Optional[Neutralization_Dilution]: User Optimized

Comment:

Anti-MDC1 Antibody is suitable for use in WB and IF microscopy. Expect a band approximately ~184kDa corresponding to specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for MDC1

Target: MDC1 (Mdc1 (MDC1))

Alternative Name: MDC1

Background:

Synonyms: Nuclear factor with BRCT domains1, mediator of DNA damage checkpoint 1, Kiaa0170

Background: MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139.

Gene Name: Mdc1

Gene ID: 240087

NCBI Accession: NP_001010833

UniProt: Q5PSV9