TFAM antibody (C-Term)

Catalog No. ABIN6657693

Supplier Product No.: 100-401-x30

This Rabbit Polyclonal antibody specifically detects TFAM in WB and ELISA. It exhibits reactivity toward Mouse.

Quick Overview for TFAM antibody (C-Term) (ABIN6657693)

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFAM antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TFAM Antibody

Binding Specificity: C-Term

Supplier Product No.: 100-401-x30

Supplier: Rockland

Purpose: TFAM Antibody

Purification: Anti-TFAM Antibody is a prepared sterile filtered neat serum.

Sterility: Sterile filtered

Immunogen: Anti-TFAM Antibody was produced in rabbits by repeated immunizations with a native recombinant mouse TFAM protein with c-terminal 6-his tag.

Isotype: IgG

Application Details

Application Notes:

ELISA_Dilution: 1:20,000

Western_Blot_Dilution: 1:2000

Comment:

Anti-TFAM Antibody has been tested in Western Blots and is specific for the ~24 kDa TFAM protein. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: None

Stabilizer: None

Preservative: None

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Expiry Date: 12 months

Target Details for TFAM

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Alternative Name: TFAM

Background:

Synonyms: Transciption factor A mitochondrial, mtTFA, Testis-specific high mobility group protein, TS-HMG

Background: Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia. More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice. TFAM Antibody is ideal for researchers interested in neuroscience research.

Gene Name: TFAM

Gene ID: 21780

NCBI Accession: NP_033386

UniProt: P40630

Pathways: Chromatin Binding