WDR5 antibody (Internal Region)

Catalog No. ABIN6657813

Supplier Product No.: 100-401-v89

Product Details anti-WDR5 Antibody

Target: WDR5 (WD Repeat Domain 5 (WDR5))

Binding Specificity: Internal Region

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Supplier Product No.: 100-401-v89

Supplier: Rockland

Purpose: Wdr5 Antibody

Cross-Reactivity (Details): Cross reactivity with Wdr5 from other species not tested.

Purification: Anti-Wdr5 Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Sterility: Sterile filtered

Immunogen: Anti-Wdr5 Antibody was produced in rabbits by repeated immunizations with two synthetic peptides containing an amino acid sequence from the internal part of mouse Wdr5.

Isotype: IgG

Application Details

Application Notes:

ELISA_Dilution: 1:100 - 1:500

Western_Blot_Dilution: 1:1,000

Comment:

Anti-Wdr5 Antibody has been tested by ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 36 kDa in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: None

Stabilizer: None

Preservative: 0.05 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for WDR5

Target: WDR5 (WD Repeat Domain 5 (WDR5))

Alternative Name: Wdr5 (WDR5 Products)

Background:

Synonyms: WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WD repeat-containing protein BIG-3, Big, Big3

Background: Wdr5 belongs to the family of WD repeat proteins which are involved in different cellular processes such as cell cycle progression, signal transduction, apoptosis, and gene regulation. It is a component of the Set1A and Set1B histone H3 methylation complexes. These complexes methylate lysine 4 of H3, thereby activating gene transcription. Wdr5 interacts with H3 dimethyl K4, but not with tri or mono methylated H3K4. Anti-Wdr5 Antibody is ideal for research in Cell Cycle Control, Signal Transduction, Apoptosis, Epigenetics, Gene Expression and Cancer.

Gene Name: Wdr5

Gene ID: 140858

NCBI Accession: NP_543124

UniProt: P61965