CD40 antibody (N-Term)

Catalog No. ABIN6657891

Supplier Product No.: 600-401-p53

This Rabbit Polyclonal antibody specifically detects CD40 in WB. It exhibits reactivity toward Mouse.

Quick Overview for CD40 antibody (N-Term) (ABIN6657891)

Target: CD40

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD40 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CD40 Antibody

Binding Specificity: N-Term

Supplier Product No.: 600-401-p53

Supplier: Rockland

Purpose: CD40 Antibody

Cross-Reactivity (Details): Anti-CD40 antibody is directed against mouse CD40 protein.

Purification: The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: CD40 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a sequence at the N-terminal of mouse CD40.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 0.5 μg/mL

Comment:

Anti-CD40 is tested for Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~32.1 kDa corresponding to the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution:

Reconstitution_Buffer: Restore with deionized water (or equivalent)

Reconstitution_Volume: 200μL

Buffer:

Buffer: 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide

Stabilizer: 5 mg BSA

Preservative: 0.05 mg Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. After reconstitution, at 4°C for one month. Aliquot and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CD40

Target: CD40

Alternative Name: CD40

Background:

Synonyms: B-cell surface antigen CD40,Bp50,CD40L receptor,CD_antigen=CD40,

Background: CD40 is a cell surface receptor that is expressed on the surface of all mature B cells and also expressed on monocytes, dendritic cells, and thymic epithelium .CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily and is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin. This antibody is suitable for researchers interested in cancer research.

Gene Name: CD40

Gene ID: 21939

NCBI Accession: NP_035741

UniProt: P27512

Pathways: NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints