KDM5B antibody (Internal Region)

Catalog No. ABIN6657904

Product Details anti-KDM5B Antibody

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Binding Specificity: Internal Region

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM5B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Cross reactivity with Jarid1b from other species not tested.

Purification: Anti-Jarid1b Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.

Immunogen:

Immunogen: Anti-Jarid1b Antibody was produced in rabbits by repeated immunizations with a synthetic peptide containing an amino acid sequence from the internal part of mouse Jarid1b.

Immunogen Type: Peptide

Application Details

Application Notes:

Application Note: Anti-Jarid1b Antibody is suitable for ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 175 kDa in the appropriate cell lysate or extract.

ELISA Dilution: 1:100 - 1:200

Western Blot Dilution: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

0.01 % (w/v) Sodium Azide

Stabilizer: None

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: RT,4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Target Details for KDM5B

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Alternative Name: Jarid1b (KDM5B Products)

Synonyms: jarid1b antibody, jarid1ba antibody, id:ibd5050 antibody, wu:fd15c05 antibody, cb264 antibody, jarid1bb antibody, plu1 antibody, wu:fc44h11 antibody, zgc:85741 antibody, JARID1B antibody, CT31 antibody, PLU-1 antibody, PLU1 antibody, PUT1 antibody, RBBP2H1A antibody, 2010009J12Rik antibody, 2210016I17Rik antibody, AW556288 antibody, D1Ertd202e antibody, Jarid1b antibody, Plu1 antibody, Rb-Bp2 antibody, mKIAA4034 antibody, RGD1565602 antibody, lysine (K)-specific demethylase 5Ba antibody, lysine (K)-specific demethylase 5Bb antibody, lysine demethylase 5B antibody, lysine (K)-specific demethylase 5B antibody, kdm5ba antibody, kdm5bb antibody, KDM5B antibody, Kdm5b antibody

Background:

Synonyms: Lysine-specific demethylase 5B, Histone demethylase JARID1B, Jumonji/ARID domain-containing protein 1B, PLU-1

Background: JARID1B is a histone demethylase which specifically demethylates mono-, di, and trimethylated lysine 4 of histone H3. It acts as a transcriptional repressor for the tumor suppressor genes BRCA1 and HOXA5 and has been associated with breast cancer development. In contrast, in melanoma JARID1B itself may function as a tumor suppressor. Anti-Jarid1b Antibody is ideal for research in Epigenetics, Chromatin Remodeling and Cancer.

Gene Name: Kdm5b

Gene ID: 10765

NCBI Accession: NP_006609

UniProt: Q9UGL1

Pathways: Warburg Effect