SNCA antibody (pSer129)

Catalog No. ABIN6658101

Supplier Product No.: 612-401-c70

This Rabbit Polyclonal antibody specifically detects SNCA in WB and ELISA. It exhibits reactivity toward Rat.

Quick Overview for SNCA antibody (pSer129) (ABIN6658101)

Target: SNCA (Synuclein, alpha (SNCA))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNCA antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SNCA Antibody

Binding Specificity: pSer129

Supplier Product No.: 612-401-c70

Supplier: Rockland

Purpose: Alpha Synuclein phospho S129 Antibody

Cross-Reactivity (Details): Anti-Alpha Synuclein pS129 Antibody is directed against rat Alpha-synuclein phosphorylated at S129.

Purification: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Immunogen: Anti-Alpha Synuclein pS129 Antibody was produced by repeated immunizations with a synthetic phospho peptide corresponding to amino acid residues surrounding Ser129.

Isotype: IgG

Application Details

Application Notes:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Comment:

Alpha Synuclein pS129 antibody is tested for use in ELISA, Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 15 kDa in size corresponding to the alpha synuclein protein phosphorylated at Ser129 in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: Alpha Synuclein

Background:

Synonyms: Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor

Background: Alpha Synuclein pS129 Antibody detects Alpha-synuclein phosphorylated at S129. Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Recent evidence suggests that phosphorylation of alpha-synuclein at Ser129 plays a role in the formation of inclusions in PD. Anti-Alpha-synuclein pS129 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: SNCA

Gene ID: 29219

NCBI Accession: NP_062042

UniProt: P37377

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity