GRM7 antibody (pSer862)

Catalog No. ABIN6658162

Supplier Product No.: 600-401-d78

The Rabbit Polyclonal anti-GRM7 antibody has been validated for WB. It is suitable to detect GRM7 in samples from Rat.

Quick Overview for GRM7 antibody (pSer862) (ABIN6658162)

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GRM7 Antibody

Binding Specificity: pSer862

Supplier Product No.: 600-401-d78

Supplier: Rockland

Purpose: mGluR7 phospho S862 Antibody

Cross-Reactivity (Details): Anti mGluR7 pS862 antibody is directed against mGluR7 phosphorylated at Ser862.

Purification: GluR7 antibody is affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-mGluR7 pS862 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser 862 conjugated to KLH.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-mGluR7 pS862 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 102 kDa in size corresponding to the mGluR7 protein phosphorylated at Ser862 in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for GRM7

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Alternative Name: mGluR7

Background:

Synonyms: mGluR7, Metabotropic Glutamate Receptor 7

Background: mGluR7 pS862 antibodiy detects mGluR7 when phosphorylated at Ser862. Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse. The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1. Therefore, mGluR7 pS862 antibody is ideal for investigators involved in neuronal circuitry and more generally in Neuroscience.

Gene Name: GRM7

Gene ID: 81672

UniProt: P35400

Pathways: Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour