Glutamate Receptor 1 antibody (N-Term)

Catalog No. ABIN6658217

Supplier Product No.: 200-301-d61

This anti-Glutamate Receptor 1 antibody is a Mouse Monoclonal antibody detecting Glutamate Receptor 1 in WB. Suitable for Rat. This Primary Antibody has been cited in 1 publication.

Quick Overview for Glutamate Receptor 1 antibody (N-Term) (ABIN6658217)

Target: Glutamate Receptor 1 (GLUR1)

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Glutamate Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RH95

Product Details anti-Glutamate Receptor 1 Antibody

Binding Specificity: N-Term

Supplier Product No.: 200-301-d61

Supplier: Rockland

Purpose: GluR1 Antibody

Cross-Reactivity (Details): Anti-GluR1 Monoclonal Antibody is directed against rat GluR1 protein.

Purification: The antibody was Protein G purified from cell culture supernatant.

Immunogen: Anti-GluR1 Monoclonal Antibody was produced by repeated immunizations with GluR1- Synthetic peptide corresponding to amino acid residues from the N-terminal region.

Isotype: IgG2a

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Suggested Applications: IF
Anti-GluR1 (Mouse) antibody has been tested by Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 100 kDa in size corresponding to GluR1 proteins in Western Blot in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

References for anti-Glutamate Receptor 1 antibody (ABIN6658217)

Domínguez-Sala, Andreu-Cervera, Martín-Climent, Murcia-Ramón, Martínez, Geijo-Barrientos: "Properties of the epileptiform activity in the cingulate cortex of a mouse model of LIS1 dysfunction." in: Brain structure & function, Vol. 227, Issue 5, pp. 1599-1614, (2022) (PubMed).

Target Details for Glutamate Receptor 1

Target: Glutamate Receptor 1 (GLUR1)

Alternative Name: GluR1

Background:

Synonyms: Glutamate receptor 1, GluR1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1,

Background: GluR1 Monoclonal Antibody detects GluR1. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. GluR1 monoclonal antibody is ideal for investigators involved in Neuroscience.

Gene Name: GRIA1

Gene ID: 50592

UniProt: P19490

Pathways: PI3K-Akt Signaling