GABBR2 antibody (pSer783)

Catalog No. ABIN6658229

Supplier Product No.: 612-401-d53

This anti-GABBR2 antibody is a Rabbit Polyclonal antibody detecting GABBR2 in WB, IHC and FM. Suitable for Rat. This Primary Antibody has been cited in 1 publication.

Quick Overview for GABBR2 antibody (pSer783) (ABIN6658229)

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABBR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Product Details anti-GABBR2 Antibody

Binding Specificity: pSer783

Supplier Product No.: 612-401-d53

Supplier: Rockland

Purpose: GABA(B) Receptor 2 phospho S783 Antibody

Cross-Reactivity (Details): Anti-GABA(B) Receptor 2 pS783 Antibody is directed against rat phosphorylated GABA(B) Receptor 2.

Purification: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GABA(B) Receptor 2 pS783 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser 783 of rat GABAB R2.

Isotype: IgG

Application Details

Application Notes:

IF_Microscopy_Dilution: 1:500

Western_Blot_Dilution: 1:1000

Comment:

Anti-GABA(B) Receptor 2 pS783 (Rabbit) antibody is tested for use in Western Blotting, ICC, and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 102 kDa in size corresponding to GABA(B) receptor 2 protein phosphorylated at Ser783 in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

References for anti-GABBR2 antibody (ABIN6658229)

Wu, Kuo, Min, Chen, Yang: "Extracellular Signal-Regulated Kinases Mediate an Autoregulation of GABAB-Receptor-Activated Whole-Cell Current in Locus Coeruleus Neurons." in: Scientific reports, Vol. 10, Issue 1, pp. 7869, (2020) (PubMed).

Target Details for GABBR2

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Alternative Name: GABA(B) Receptor 2

Background:

Synonyms: Gamma-aminobutyric acid type B receptor subunit 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51

Background: Anti-GABA(A) Receptor 2 pS783 Antibody detects phosphorylated GABA(A) Receptor 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors and phosphorylates S783 in the cytoplasmic tail of the R2 subunit and that S783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of S783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain. GABA(B) Receptor 2 pS783 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABBR2

Gene ID: 83633, 8393403

UniProt: O88871

Pathways: cAMP Metabolic Process