GABRA3 antibody (N-Term)
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- Target See all GABRA3 Antibodies
- GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))
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Binding Specificity
- N-Term
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Reactivity
- Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GABRA3 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Cross-Reactivity
- Mouse (Murine), Rat (Rattus)
- Purification
- Anti-GABA(A) Receptor alpha 3 antibody is directed against human GABA(A) Receptor alpha 3. The antibody was affinity purified from monospecific antibodies by immunoaffinity purification. Labeling is absent in α3-subunit knockout animals. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, human, non-human primates, and Zebrafish.
- Immunogen
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Immunogen: Anti-GABA(A) Receptor alpha 3 Antibody was produced by repeated immunizations with a synthetic peptide from the N-terminal region of the alpha 3 subunit.
Immunogen Type: Peptide
- Isotype
- IgG
- Top Product
- Discover our top product GABRA3 Primary Antibody
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- Application Notes
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Immunohistochemistry Dilution: 1:100
Application Note: Anti-GABA(A) Receptor alpha 3 (Rabbit) antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 51 kDa in size corresponding to the alpha 3 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.
Western Blot Dilution: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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- Target
- GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))
- Alternative Name
- GABA(A) Receptor alpha 3 (GABRA3 Products)
- Synonyms
- GABRA3 antibody, Gabra-3 antibody, si:ch211-113k9.1 antibody, gamma-aminobutyric acid type A receptor alpha3 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, alpha 3 antibody, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 antibody, gamma-aminobutyric acid receptor subunit alpha-3 antibody, GABRA3 antibody, gabra3 antibody, Gabra3 antibody, LOC100653496 antibody
- Background
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Synonyms: Gamma-aminobutyric acid receptor subunit alpha-3, GABA(A) receptor subunit alpha-3
Background: GABA(A) Receptor alpha 3 antibody detects GABA(A) Receptor alpha 3. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Anti-GABA(A) Receptor alpha 3 Antibody is ideal for investigators involved in Neuroscience.
Gene Name: GABRA3
- Gene ID
- 24947
- NCBI Accession
- NP_058765
- UniProt
- P20236
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