ADRB1 antibody (AA 181-250)

Catalog No. ABIN669351

This anti-ADRB1 antibody is a Rabbit Polyclonal antibody detecting ADRB1 in WB, ELISA, FACS, IF (cc), IF (p), ICC, IHC (p) and IHC (fro). Suitable for Human, Rat and Mouse. This Primary Antibody has been cited in 2+ publications.

Quick Overview for ADRB1 antibody (AA 181-250) (ABIN669351)

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ADRB1 Antibody

Binding Specificity: AA 181-250

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADRB1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-ADRB1 antibody (ABIN669351)

Bornholz, Benninghaus, Reinke, Felix, Roggenbuck, Jahns-Boivin, Jahns, Boege: "A standardised FACS assay based on native, receptor transfected cells for the clinical diagnosis and monitoring of ?1-adrenergic receptor autoantibodies in human heart disease." in: Clinical chemistry and laboratory medicine : CCLM / FESCC, (2015) (PubMed).

Deng, Liu, Zhang, Wang, Peng, Wei, Jiang: "Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model." in: Journal of experimental & clinical cancer research : CR, Vol. 33, pp. 21, (2014) (PubMed).

Target Details for ADRB1

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Alternative Name: ADRB1

Background:

Synonyms: RHR, B1AR, ADRB1R, BETA1AR, Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor, ADRB1

Background: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

Gene ID: 153

UniProt: P08588

Pathways: cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Brown Fat Cell Differentiation