Thrombomodulin antibody

Catalog No. ABIN669636

This anti-Thrombomodulin antibody is a Rabbit Polyclonal antibody detecting Thrombomodulin in WB, IHC (p) and IF (p). Suitable for Human, Rat, Mouse, Dog and Cow.

Quick Overview for Thrombomodulin antibody (ABIN669636)

Target: Thrombomodulin (THBD)

Reactivity: Human, Rat, Mouse, Dog, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thrombomodulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Thrombomodulin Antibody

Cross-Reactivity: Cow, Dog, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Thrombomodulin

Isotype: IgG

Application Details

Application Notes: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Thrombomodulin

Target: Thrombomodulin (THBD)

Alternative Name: Thrombomodulin

Background:

Synonyms: Thrombomodulin, CD 141, CD141, CD141 antigen, Fetomodulin, THBD, THRM, TM, AHUS 6, AHUS6, BDCA 3, BDCA3, THPH12, TRBM_HUMAN.

Background: Thrombomodulin, TM is cell surface glycoprotein, plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules.CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII, thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Molecular Weight: 61kDa

Gene ID: 21824