tau antibody (PE)

Catalog No. ABIN6698783

The Rabbit Polyclonal anti-tau antibody has been validated for WB and ELISA. It is suitable to detect tau in samples from Human and Mouse.

Quick Overview for tau antibody (PE) (ABIN6698783)

Target: tau (tau Protein)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This tau antibody is conjugated to PE

Application: Western Blotting (WB), ELISA

Product Details anti-tau Antibody (PE)

Specificity: Detects ~45.8kda.

Purification: Protein A Purified

Immunogen: Synthetic peptide from the full length of Human Tau

Application Details

Application Notes:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.
• optimal dilutions for assays should be determined by the user.

Comment:

A 1:1000 dilution of ABIN6698783 was sufficient for detection of Tau in 10 μg of human SH-SY5Y cell lysate cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Target Details for tau

Target: tau (tau Protein)

Alternative Name: Tau

Background: Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).

Gene ID: 4137

UniProt: P10636