EMP1 antibody (AA 101-160)

Catalog No. ABIN670086

The Rabbit Polyclonal anti-EMP1 antibody (ABIN670086) specifically detects EMP1 in IF (cc), IF (p), IHC (fro) and IHC (p). The antibody is reactive with Mouse samples.

Quick Overview for EMP1 antibody (AA 101-160) (ABIN670086)

Target: EMP1 (Epithelial Membrane Protein 1 (EMP1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EMP1 antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-EMP1 Antibody

Binding Specificity: AA 101-160

Purpose: EMP-1 Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Emp1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for EMP1

Target: EMP1 (Epithelial Membrane Protein 1 (EMP1))

Alternative Name: EMP1

Background:

Synonyms: TMP, I-8-9, Epithelial membrane protein 1, EMP-1, Tumor-associated membrane protein, Emp1

Background: Epithelial membrane protein-1 (EMP-1) is a four pass transmembrane protein consisting of 160 amino acids. It is a member of a small family of epithelial membrane proteins. EMP-1 is very similar in structure to its close relative, Peripheral Myelin Protein 22 (PMP22). It is most predominantly expressed in tissues of the gastrointestinal tract but has also been found to be a junctional protein in the liver expressed along the intercellular border. EMP-1 directly interacts with the C-terminus of the P2X7 receptor and may be involved in membrane blebbing. EMP-1 may also be an important regulator in cell communication, signaling, and adhesion. When EMP-1 is overexpressed, cell proliferation is inhibited, S phase is arrested and G1 phase is prolonged in esophogeal cancer cells. EMP-1 may play a role in tumorigenesis and has been identified as a biomarker for gefitinib treatment resistance for patients with lung cancer.

Gene ID: 13730

UniProt: P47801