CTGF antibody (AA 221-349)

Catalog No. ABIN672636

Cited in 5+ publications. The Rabbit Polyclonal anti-CTGF antibody (ABIN672636) specifically detects CTGF in WB, IHC (p), IF (p), IF (cc) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for CTGF antibody (AA 221-349) (ABIN672636)

Target: CTGF (Connective Tissue Growth Factor (CTGF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTGF antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CTGF Antibody

Binding Specificity: AA 221-349

Purpose: CTGF Polyclonal Antibody

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Dog,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CTGF

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), IHC-P(1:200-400), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CTGF antibody (ABIN672636)

Han, Zhang, Zhong, Wang, Zhang, Chen: "MicroRNA-145 Inhibits Cell Migration and Invasion and Regulates Epithelial-Mesenchymal Transition (EMT) by Targeting Connective Tissue Growth Factor (CTGF) in Esophageal Squamous Cell Carcinoma." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 22, pp. 3925-3934, (2017) (PubMed).

Al-Hamilly, Radwan, Abdul-Rahman, Mourad, Grawish: "Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study." in: Archives of oral biology, Vol. 66, pp. 38-43, (2016) (PubMed).

Ciamporcero, Shen, Ramakrishnan, Yu Ku, Chintala, Shen, Adelaiye, Miles, Ullio, Pizzimenti, Daga, Azabdaftari, Attwood, Johnson, Zhang, Barrera, Pili: "YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage." in: Oncogene, (2015) (PubMed).

Guo, Zhang, Mu, Liu, Yuan, Ren, Wang: "High-salt intake suppressed microRNA-133a expression in Dahl SS rat myocardium." in: International journal of molecular sciences, Vol. 15, Issue 6, pp. 10794-805, (2015) (PubMed).

Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: "Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats." in: International journal of clinical and experimental pathology, Vol. 7, Issue 6, pp. 3028-37, (2014) (PubMed).

Target Details for CTGF

Target: CTGF (Connective Tissue Growth Factor (CTGF))

Alternative Name: CTGF

Background:

Synonyms: CCN2, NOV2, HCS24, IGFBP8, Connective tissue growth factor, CCN family member 2, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8, CTGF

Background: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Gene ID: 1490

UniProt: P29279

Pathways: Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Growth Factor Binding