PPP1R13B antibody (Protein Phosphatase 1, Regulatory Subunit 13B)

Details for Product anti-PPP1R13B Antibody No. ABIN674379, Supplier: Log in to see
Antigen
  • pp2ca1
  • ppp1r13b
  • si:ch211-253p18.1
  • wu:fd42g12
  • zgc:153820
  • AI449786
  • ASPP1
  • AW545810
  • Tp53bp2
  • Trp53bp2
  • p85
  • p53BP2-like
  • protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
  • protein phosphatase 1 regulatory subunit 13B
  • protein phosphatase 1, regulatory (inhibitor) subunit 13B
  • protein phosphatase 1, regulatory subunit 13Bb
  • protein phosphatase 1 regulatory subunit 13B L homeolog
  • protein phosphatase 1, regulatory subunit 13B
  • ppm1ab
  • PPP1R13B
  • ppp1r13b
  • Ppp1r13b
  • ppp1r13bb
  • ppp1r13b.L
Alternatives
anti-Human PPP1R13B antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Rattus)
66
31
27
2
2
2
2
1
1
1
1
1
1
Host
Rabbit
66
1
Clonality
Polyclonal
Conjugate
This PPP1R13B antibody is un-conjugated
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
47
30
12
5
5
4
2
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide derived from human ASPP1
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PPP1R13B products on genomics-online (e.g. as negative or positive controls)
Antigen Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B)
Alternative Name Aspp1 (PPP1R13B Antibody Abstract)
Background

iASPP (inhibitor of apoptosis stimulating protein of p53, RelA-associated inhibitor (RAI), NFKap B-interacting protein 1, protein phosphatase 1 regulatory subunit 13-like, PPP1R13L) is the third member of the ASPP family of proteins. Unlike ASPP1 and ASPP2, which interact with p53 and enhance its ability to induce apoptosis, iASPP inhibits apoptosis induced by p53 overexpression. iASPP has been identified in a yeast-two hybrid screen as an interacting protein of the p65 subunit of NFKap B (RelA),3 interacts with NFKap B in vivo, and acts as an efficient inhibitor of HIV-1 gene expression in which both NFKap b and Sp1 play major roles. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53, and gene overexpression may play an important role in the leukemogenesis and/or progression of acute leukemia. Alternate Names: apoptosis stimulating protein of P53 1, Apoptosis-stimulating of p53 protein 2, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2, 53BP2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51.

Subcellular location: Cytoplasm

Synonyms: p53BP2 like, p85, PPP1R13B, apoptosis stimulating protein of P53 1, Apoptosis-stimulating of p53 protein 2, Tumor suppressor p53-binding protein 2, p53-binding protein 2, p53BP2, 53BP2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51.

Gene ID 23368
UniProt Q96KQ4
Pathways p53 Signaling
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Product cited in: Xie, Yang, Chi, Yang, Wang, Xu: "Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study." in: Chinese journal of cancer, Vol. 36, Issue 1, pp. 15, 2017 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human). Further details: Sample: ESCC

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