CD40 Ligand antibody (AA 31-150)

Catalog No. ABIN674439

Cited in 2+ publications. The Rabbit Polyclonal anti-CD40 Ligand antibody (ABIN674439) specifically detects CD40 Ligand in WB, FACS, IHC (p), IF (p), IF (cc) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for CD40 Ligand antibody (AA 31-150) (ABIN674439)

Target: CD40 Ligand (CD40LG)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD40 Ligand antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CD40 Ligand Antibody

Binding Specificity: AA 31-150

Purpose: CD40L Polyclonal Antibody

Cross-Reactivity: Human, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD40L/CD154

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CD40 Ligand antibody (ABIN674439)

Zhang, Song, Shu, Li, Wu, Wang, Chen, Chang, Wu, Zhang, Wei: "BAFF upregulates CD28/B7 and CD40/CD154 expression and promotes mouse T and B cell interaction in vitro via BAFF receptor." in: Acta pharmacologica Sinica, Vol. 37, Issue 8, pp. 1101-9, (2016) (PubMed).

Rui-Kai, Jian: "Effects of xinfeng capsules on expression of platelet granule membrane protein 140 and platelet cluster of differentiation 40 ligand in peripheral blood of adjuvant arthritis rats." in: International journal of rheumatology, Vol. 2012, pp. 139696, (2012) (PubMed).

Target Details for CD40 Ligand

Target: CD40 Ligand (CD40LG)

Alternative Name: CD40L/CD154

Background:

Synonyms: IGM, IMD3, TRAP, gp39, CD154, CD4L, HIGM1, T-BAM, TNFSF5, hCD4L, CD4 ligand, CD4-L, T-cell antigen Gp39, TNF-related activation protein, Tumor necrosis factor ligand superfamily member 5, CD4LG

Background: Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD4L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Gene ID: 959

UniProt: P29965

Pathways: NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints