CD51/CD61 antibody

Catalog No. ABIN674784

Cited in 10+ publications. The Rabbit Polyclonal anti-CD51/CD61 antibody (ABIN674784) specifically detects CD51/CD61 in FACS, WB, IHC (fro), IF (cc), IF (p) and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CD51/CD61 antibody (ABIN674784)

Target: CD51/CD61 (ITGAV/ITGB3) (Integrin alpha V, Integrin beta 3 (ITGAV/ITGB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD51/CD61 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CD51/CD61 Antibody

Purpose: Integrin Alpha V Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Integrin Alpha V

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CD51/CD61 antibody (ABIN674784)

Bian, Ma, Jain, Crane, Kebaish, Wan, Zhang, Edward Guo, Sponseller, Séguin, Riley, Wang, Cao: "Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis." in: Bone research, Vol. 5, pp. 17008, (2017) (PubMed).

Li, Xiong, Gong: "Lyn kinase enhanced hepatic fibrosis by modulating the activation of hepatic stellate cells." in: American journal of translational research, Vol. 9, Issue 6, pp. 2865-2877, (2017) (PubMed).

Chen, Chen, Kemper, Brigstock: "Pathways of production and delivery of hepatocyte exosomes." in: Journal of cell communication and signaling, (2017) (PubMed).

Li, Zhou, Li, Zhang, Shao, Tang, Tian: "Effects of Cationic Microbubble Carrying CD/TK Double Suicide Gene and αVβ3 Integrin Antibody in Human Hepatocellular Carcinoma HepG2 Cells." in: PLoS ONE, Vol. 11, Issue 7, pp. e0158592, (2017) (PubMed).

Chen, Zheng, Liu, Shi, Qi: "Periostin activates pathways involved in epithelial-mesenchymal transition in adamantinomatous craniopharyngioma." in: Journal of the neurological sciences, Vol. 360, pp. 49-54, (2016) (PubMed).

Chen, Brigstock: "Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes." in: FEBS letters, Vol. 590, Issue 23, pp. 4263-4274, (2016) (PubMed).

Muschter, Göttl, Vogel, Grifka, Straub, Grässel: "Reactivity of rat bone marrow-derived macrophages to neurotransmitter stimulation in the context of collagen II-induced arthritis." in: Arthritis research & therapy, Vol. 17, pp. 169, (2016) (PubMed).

Jiang, Tu, Kimura, Habte, Chen, Cheng, Shi, Gambhir, Cheng: "64Cu-Labeled Divalent Cystine Knot Peptide for Imaging Carotid Atherosclerotic Plaques." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 56, Issue 6, pp. 939-44, (2015) (PubMed).

Mondal, Barui, Chaudhuri: "The relationship between the cyclic-RGDfK ligand and ?v?3 integrin receptor." in: Biomaterials, Vol. 34, Issue 26, pp. 6249-60, (2013) (PubMed).

Target Details for CD51/CD61

Target: CD51/CD61 (ITGAV/ITGB3) (Integrin alpha V, Integrin beta 3 (ITGAV/ITGB3))

Alternative Name: Integrin Alpha V + Beta 3

Background:

Synonyms: CD51, Integrin alpha five, integrin alpha V beta 3, Integrin alpha-V light chain, ITGAV, Msk8,Vitronectin receptor subunit alpha, VNRA, VTNR.

Background: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Gene ID: 3685

UniProt: P06756