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MCM3 antibody (AA 251-350) (HRP)

The Rabbit Polyclonal anti-MCM3 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect MCM3 in samples from Human.
Catalog No. ABIN676262

Quick Overview for MCM3 antibody (AA 251-350) (HRP) (ABIN676262)

Target

See all MCM3 Antibodies
MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Reactivity

  • 85
  • 32
  • 26
  • 7
  • 5
  • 5
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 77
  • 7
  • 3
Rabbit

Clonality

  • 69
  • 18
Polyclonal

Conjugate

  • 49
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This MCM3 antibody is conjugated to HRP

Application

  • 49
  • 29
  • 20
  • 16
  • 16
  • 15
  • 14
  • 14
  • 11
  • 6
  • 2
  • 2
  • 2
  • 2
  • 1
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

    • 14
    • 8
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-350

    Predicted Reactivity

    Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human MCM3

    Isotype

    IgG
  • Application Notes

    IHC-P 1:200-400
    IHC-F 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handling Advice

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

    Alternative Name

    MCM3

    Background

    Synonyms: minichromosome maintenance deficient 3, Cervical cancer proto oncogene 5, DNA polymerase alpha holoenzyme associated P1, DNA polymerase alpha holoenzyme associated protein P1, DNA replication factor MCM3, DNA replication licensing factor MCM3, HCC 5, HCC5, hRlf beta subunit, Human cervical cancer proto oncogene 5, MCM 3, MCM3 minichromosome maintenance deficient 3, MGC1157, Minichromosome maintenance deficient 3, Minichromosome maintenance protein 3, P1 h, P1 MCM3, P1 Protein, P1.h, P102 protein, Replication licensing factor beta subunit, RLF beta subunit, RLF subunit beta, RLFB.

    Background: MCM3 is one of the highly conserved mini-chromosome maintenance proteins that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.

    Gene ID

    4172

    Pathways

    DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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