CRHR2 antibody (AA 51-150)

Catalog No. ABIN680773

This Rabbit Polyclonal antibody specifically detects CRHR2 in WB, ELISA, IF (cc) and IF (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for CRHR2 antibody (AA 51-150) (ABIN680773)

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRHR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CRHR2 Antibody

Binding Specificity: AA 51-150

Specificity: This antibody may cross react with CRHR1.

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CRHR2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CRHR2

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Alternative Name: CRHR2

Background:

Synonyms: CRF2, CRFR2, CRF-RB, HM-CRF, Corticotropin-releasing factor receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-releasing hormone receptor 2, CRH-R-2, CRH-R2, CRHR2, CRF2R, CRH2R

Background: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Gene ID: 1395

UniProt: Q13324

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Feeding Behaviour