GAB2 antibody (AA 601-676)

Catalog No. ABIN681178

This Rabbit Polyclonal antibody specifically detects GAB2 in WB, IF (cc), IF (p), FACS, IHC (p) and IHC (fro). It exhibits reactivity toward Human. It has been mentioned in 3+ publications

Quick Overview for GAB2 antibody (AA 601-676) (ABIN681178)

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GAB2 Antibody

Binding Specificity: AA 601-676

Purpose: Gab2 Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gab2

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-GAB2 antibody (ABIN681178)

Hu, Liao, Xu, Ruan, Gao: "K48-Linked Ubiquitination Contributes to Nicotine-Augmented Bone Marrow-Derived Dendritic-Cell-Mediated Adaptive Immunity." in: Vaccines, Vol. 9, Issue 3, (2021) (PubMed).

You, Xu, Zhang, Chen, Gao: "PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation." in: Journal of immunology research, Vol. 2018, pp. 5070573, (2018) (PubMed).

Zhan, Xu, Chen, Wang, Yanfeng, Dan, Zhan, Shi: "Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model." in: Synapse (New York, N.Y.), Vol. 68, Issue 4, pp. 168-77, (2014) (PubMed).

Target Details for GAB2

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Alternative Name: Gab2

Background:

Synonyms: GRB2-associated-binding protein 2, GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2, pp1, GAB2, KIAA571

Background: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Gene ID: 9846

UniProt: Q9UQC2

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, Warburg Effect