C3 antibody (Complement Component 3) (AA 1611-1631)

Details for Product anti-C3 Antibody No. ABIN681913, Supplier: Log in to see
Antigen
  • AHUS5
  • ARMD9
  • ASP
  • C3a
  • C3b
  • CPAMD1
  • AI255234
  • HSE-MSF
  • Plp
  • C3
  • C3-1
  • sb:cb26
  • si:dkey-76b14.4
  • wu:fi34b03
  • wu:fj86e11
  • C3d
  • asp
  • cpamd1
  • c3
  • complement C3
  • complement component 3
  • complement component c3a, duplicate 1
  • complement component 3 L homeolog
  • complement component C3
  • complement C3-like
  • C3
  • c3a.1
  • c3.L
  • LOC443475
  • c3
  • c3-1
  • LOC100060539
Alternatives
anti-Human C3 antibody for ELISA
Epitope
AA 1611-1631
15
14
6
6
5
5
4
4
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
284
78
65
15
15
9
7
6
5
4
3
1
Host
Rabbit
160
131
95
27
14
7
Clonality
Polyclonal
Conjugate
This C3 antibody is un-conjugated
38
37
23
7
7
5
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
223
198
101
71
68
60
56
51
45
38
38
31
17
10
5
5
5
2
2
2
1
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide derived from human Complement C3 alpha chain
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others C3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Complement C3 (C3 Antibody Abstract)
Background

C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575).

Subcellular location: Secreted

Synonyms: ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3

Gene ID 718
UniProt P01024
Pathways Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
Application Notes IHC-P 1:100-500
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunofluorescence (IF) image for anti-Complement Component 3 (C3) (AA 1611-1631) antibody (ABIN681913) Formalin-fixed and paraffin embedded rat liver labeled with Anti-C3 Polyclonal Antibo...
Immunofluorescence (IF) image for anti-Complement Component 3 (C3) (AA 1611-1631) antibody (ABIN681913) Formalin-fixed and paraffin embedded mouse kidney labeled with Anti-C3 Polyclonal Ant...
ELISA image for anti-Complement Component 3 (C3) (AA 1611-1631) antibody (ABIN681913) Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:...
Product cited in: Zhuang, Han, Li, Kienhöfer, Lee, Shumyak, Meyerholz, Rosadzinski, Rosner, Chan, Xu, Segal, Sobel, Yang, Hoffmann, Reeves: "A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 68, Issue 12, pp. 2917-2928, 2016 (PubMed). Method employed by authors: ELISA (ELISA) Further details: Sample: serum

Trang, Hirai, Nabeta, Fuke, Yamaguchi: "Membranoproliferative glomerulonephritis in a calf with nephrotic syndrome." in: Journal of comparative pathology, Vol. 151, Issue 2-3, pp. 162-5, 2014 (PubMed). (Sample species: Cow (Bovine)). Further details: Sample: Kidney

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