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APP antibody (pThr743) (Cy5)

The Rabbit Polyclonal anti-APP antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect APP in samples from Human.
Catalog No. ABIN683087

Quick Overview for APP antibody (pThr743) (Cy5) (ABIN683087)

Target

See all APP Antibodies
APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity

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Human

Host

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Rabbit

Clonality

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  • 80
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Polyclonal

Conjugate

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This APP antibody is conjugated to Cy5

Application

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Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Binding Specificity

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    pThr743

    Predicted Reactivity

    Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human APP around the phosphorylation site of Thr743

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    APP (Amyloid beta (A4) Precursor Protein (APP))

    Alternative Name

    Amyloid Precursor Protein

    Background

    Synonyms: Amyloid Precursor Protein phospho Thr743, Amyloid Precursor Protein phospho Thr743, p-Amyloid Precursor Protein phospho Thr743, APP Thr743,

    Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

    Gene ID

    351

    UniProt

    P05067

    Pathways

    Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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