Acetyl-CoA Carboxylase antibody (pSer78)

Catalog No. ABIN683203

This Rabbit Polyclonal antibody specifically detects Acetyl-CoA Carboxylase in IF (p) and IHC (p). It exhibits reactivity toward Human and Pig.

Quick Overview for Acetyl-CoA Carboxylase antibody (pSer78) (ABIN683203)

Target: Acetyl-CoA Carboxylase

Reactivity: Human, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Acetyl-CoA Carboxylase antibody is un-conjugated

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Acetyl-CoA Carboxylase Antibody

Binding Specificity: pSer78

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Acetyl Coenzyme A carboxylase alpha around the phosphorylation site of Ser78

Isotype: IgG

Application Details

Application Notes: IHC-P (1:100-500),IF (p) (1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Acetyl-CoA Carboxylase

Target: Acetyl-CoA Carboxylase

Alternative Name: Acetyl CoA Carboxylase

Background:

Synonyms: Acetyl Coenzyme A Carboxylase alpha phospho S78, p-Acetyl Coenzyme A Carboxylase alpha phospho S78, ACAC, ACACA, ACACA, ACACA_HUMAN, ACC alpha, ACC, ACC-alpha, ACC1, ACC1, ACCA, acetyl CoA carboxylase 1, acetyl Coenzyme A, Acetyl Coenzyme A, Biotin carboxylase, Acetyl-Coenzyme A Carboxylase alpha.

Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Molecular Weight: 266kDa

Gene ID: 32