ARFIP2 antibody (AA 221-341) (FITC)

Catalog No. ABIN686594

The Rabbit Polyclonal anti-ARFIP2 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect ARFIP2 in samples from Human.

Quick Overview for ARFIP2 antibody (AA 221-341) (FITC) (ABIN686594)

Target: ARFIP2 (ADP-Ribosylation Factor Interacting Protein 2 (ARFIP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARFIP2 antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ARFIP2 Antibody (FITC)

Binding Specificity: AA 221-341

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Arfaptin 2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ARFIP2

Target: ARFIP2 (ADP-Ribosylation Factor Interacting Protein 2 (ARFIP2))

Alternative Name: Arfaptin 2

Background:

Synonyms: ARFIP2, arfaptin 2, ADP-ribosylation factor interacting protein 2, Partner of RAC1, POR1, ARFP2_HUMAN .

Background: ARFIP2 is a ubiquitously expressed protein implicated in mediating cross talk between RAC and ARF small GTPases. It has been shown that ARFIP2 binds specifically to GTP-bound ARF1 and ARF6, but binds to Rac-GTP and Rac-GDP with similar affinities. The X-ray structure of arfaptin reveals an elongated, crescent-shaped dimer of 3-helix coiled-coils. Structures of arfaptin with Rac bound to either GDP or the slowly hydrolysable analog GMPPNP show that the switch regions adopt similar conformations in both complexes.

Gene ID: 23647