RBBP6 antibody (AA 2-150) (HRP)

Catalog No. ABIN687211

This Rabbit Polyclonal antibody specifically detects RBBP6 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Mouse and Rat.

Quick Overview for RBBP6 antibody (AA 2-150) (HRP) (ABIN687211)

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBBP6 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-RBBP6 Antibody (HRP)

Binding Specificity: AA 2-150

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human P2PR

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RBBP6

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Alternative Name: RBBP6/P2P-R

Background:

Synonyms: PACT, MY038, P2P-R, RBQ-1, SNAMA, E3 ubiquitin-protein ligase RBBP6, Proliferation potential-related protein, Protein P2P-R, Retinoblastoma-binding Q protein 1, Retinoblastoma-binding protein 6, p53-associated cellular protein of testis, RBBP6, P2PR, RBQ1

Background: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.

Gene ID: 5930

UniProt: Q7Z6E9

Pathways: Regulatory RNA Pathways