RBBP6 antibody (AA 51-97)

Catalog No. ABIN7151111

Product Details anti-RBBP6 Antibody

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Binding Specificity: AA 51-97

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBBP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RBBP6 protein (51-97AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RBBP6

Target: RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))

Alternative Name: RBBP6 (RBBP6 Products)

Synonyms: MY038 antibody, P2P-R antibody, PACT antibody, RBQ-1 antibody, SNAMA antibody, 4933422O15Rik antibody, AI316869 antibody, BB233631 antibody, C030034J04Rik antibody, C77662 antibody, rbbp6 antibody, MGC75882 antibody, RBBP6 antibody, im:7158869 antibody, rbbp6l antibody, RB binding protein 6, ubiquitin ligase antibody, retinoblastoma binding protein 6, ubiquitin ligase antibody, retinoblastoma binding protein 6 antibody, RBBP6 antibody, Rbbp6 antibody, rbbp6 antibody

Background:

Background: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).

Aliases: DKFZp686P0638 antibody, DKFZp761B2423 antibody, E3 ubiquitin-protein ligase RBBP6 antibody, MY038 antibody, P2P R antibody, P2PR antibody, p53 associated cellular protein of testis antibody, p53-associated cellular protein of testis antibody, p53-associated cellular protein, testis-derived antibody, PACT antibody, Proliferation potential related protein antibody, Proliferation potential-related protein antibody, Protein P2P R antibody, Protein P2P-R antibody, Protein P2PR antibody, Protein RBQ 1 antibody, Protein RBQ1 antibody, RB binding protein 6, ubiquitin ligase antibody, RB binding Q protein 1 antibody, RBBP 6 antibody, Rbbp6 antibody, RBBP6_HUMAN antibody, RBQ 1 antibody, RBQ-1 antibody, RBQ1 antibody, Retinoblastoma binding protein 6 isoform 3 antibody, Retinoblastoma binding Q protein 1 antibody, Retinoblastoma-binding protein 6 antibody, Retinoblastoma-binding Q protein 1 antibody, SNAMA antibody, SNAMA, Drosophila, homolog of antibody

UniProt: Q7Z6E9

Pathways: Regulatory RNA Pathways