Recombinant CD207 antibody (AA 74-213)

Catalog No. ABIN6936636

The Mouse Monoclonal anti-CD207 antibody has been validated for WB, ELISA and Coat. It is suitable to detect CD207 in samples from Human.

Quick Overview for Recombinant CD207 antibody (AA 74-213) (ABIN6936636)

Target: CD207 (CD207 Molecule, Langerin (CD207))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD207 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Coating (Coat)

Clone: RLGRN-1821

Product Details anti-CD207 Antibody

Binding Specificity: AA 74-213

Specificity: Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa74-213) of human Langerin protein (exact sequence is proprietary)

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or A549 cells (WB).

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for CD207

Target: CD207 (CD207 Molecule, Langerin (CD207))

Alternative Name: CD207

Background: C-type lectin domain family 4 member K, CD207, CLEC4K, Langerhans cell specific c type lectin, Langerin,Langerin / CD207 (Marker of Langerhans Cells)
Cellular localisation: Cell surface and cytoplasmic

Molecular Weight: 48kDa

Gene ID: 50489, 199731

UniProt: Q9UJ71