Cadherin-16 antibody

Catalog No. ABIN6936885

The Rabbit Polyclonal anti-Cadherin-16 antibody is suitable to detect Cadherin-16 in samples from Human, Mouse and Rat. It has been validated for IHC.

Quick Overview for Cadherin-16 antibody (ABIN6936885)

Target: Cadherin-16 (CDH16)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin-16 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Cadherin-16 Antibody

Purpose: Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody

Specificity: This antibody recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Cross-Reactivity (Details): Human. Mouse. Rat.

Purification: 200ug/ml of Ab Purified by Protein A.

Immunogen: Recombinant human CDH16 protein

Isotype: IgG, kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Normal kidney or renal cell carcinoma.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Cadherin-16

Target: Cadherin-16 (CDH16)

Alternative Name: CDH16

Background:

Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody

Normal kidney or renal cell carcinoma.

Molecular Weight: 130kDa

Gene ID: 1014, 513660

UniProt: O75309