LHCGR antibody (AA 70-410)

Catalog No. ABIN6937783

This anti-LHCGR antibody is a Mouse Monoclonal antibody detecting LHCGR in IF and FACS. Suitable for Human.

Quick Overview for LHCGR antibody (AA 70-410) (ABIN6937783)

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LHCGR antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: LHCGR-1415

Product Details anti-LHCGR Antibody

Binding Specificity: AA 70-410

Specificity: Recognizes a protein of 78-85 kDa, which is identified as Luteinizing hormone / choriogonadotropin receptor. Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 70-410) of human LHCGR protein (exact sequence is proprietary)

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: HepG2 or Jurkat cells. Ovary or Testis.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for LHCGR

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Alternative Name: LHCGR

Background: Gonadotropin receptor, GTHR-II, HHG, LCGR, LGR2, LH-R, LH/CG-R, LH/CGR, LHCGR, LHR, LHRHR, LSH-R, Luteinizing hormone receptor, Luteinizing hormone/choriogonadotropin receptor, Lutropin choriogonadotropic receptor, Lutropin-choriogonadotropic hormone receptor, ULG5,Luteinizing Hormone / Choriogonadotropin Receptor (LHCGR)
Cellular localisation: Cytoplasmic and Cell Surface

Molecular Weight: 78-85kDa

Gene ID: 3973, 468490

UniProt: P22888

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling