Recombinant LMO2 antibody (AA 23-140)

Catalog No. ABIN6937787

Product Details anti-LMO2 Antibody

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Antibody Type: Recombinant Antibody

Binding Specificity: AA 23-140

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LMO2 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. It has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymph-angiogenesis. Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma.The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin. LMO2 is useful in differentiating follicular lymphoma (LMO2+) from nodal marginal zone lymphoma (LM02-). It also is positive in Hodgkin s and Burkitt s lymphomas.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human LMO2 protein fragment (around aa 23-140) (exact sequence is proprietary)

Clone: RLMO2-1971

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: K562, Ramos or Raji cells. Placenta, pancreas or Hodgkin s lymphoma.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for LMO2

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Alternative Name: LMO2 (LMO2 Products)

Synonyms: Rbtn-2 antibody, Rbtn2 antibody, Rhom-2 antibody, Ttg2 antibody, RBTN2 antibody, RBTNL1 antibody, RHOM2 antibody, TTG2 antibody, wu:fc83a08 antibody, zgc:111930 antibody, LMO-2 antibody, lmo2-A antibody, xlmo2 antibody, rhombotin-2 antibody, LIM domain only 2 antibody, LIM domain only 2 (rhombotin-like 1) antibody, LIM domain only 2 S homeolog antibody, lmo2 antibody, LMO2 antibody, Lmo2 antibody, lmo2.S antibody

Background: Cysteine-rich protein TTG-2, LIM domain only protein 2, LMO-2, RBTN L1, RBTN2, Rhombotin like 1, Rhombotin-2 (RHOM2), T-cell translocation protein 2, TTG2,LMO2 (B-Cell Marker)
Cellular localisation: Nuclear

Molecular Weight: 24kDa

Gene ID: 4005, 34560

UniProt: P25791

Pathways: Chromatin Binding