NKX2-8 antibody (AA 10-123)

Catalog No. ABIN6938069

This Mouse Monoclonal antibody specifically detects NKX2-8 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for NKX2-8 antibody (AA 10-123) (ABIN6938069)

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NKX2-8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: NKX28-2547

Product Details anti-NKX2-8 Antibody

Binding Specificity: AA 10-123

Specificity: The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Human recombinant NKX2.8 protein fragment (around aa 10-123) (exact sequence is proprietary)

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Western Blot (0.5 μg-1 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: PC3 or MCF-7 cells. Human Liver, Kidney or Thyroid tissue (IHC).

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for NKX2-8

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Alternative Name: NKX2-8

Background: Homeobox protein NK 2 homolog H, Homeobox protein NK-2 homolog H, Homeobox protein Nkx 2.8, Homeobox protein Nkx-2.8, NK 2 homolog 8, NK 2 homolog H, NK2 homeobox 8, NK2 transcription factor related, locus 8, Nkx2 9, Nkx2-8, NKX2.8, NKX28_HUMAN, NKX2G, NKX2H, OTTHUMP00000027959,NKX2.8
Cellular localisation: Nuclear and Cytoplasm.

Molecular Weight: 26kDa

Gene ID: 26257, 234763

UniProt: O15522