Peroxiredoxin 4 antibody

Catalog No. ABIN6938231

This Mouse Monoclonal antibody specifically detects Peroxiredoxin 4 in ELISA and Coat. It exhibits reactivity toward Human.

Quick Overview for Peroxiredoxin 4 antibody (ABIN6938231)

Target: Peroxiredoxin 4 (PRDX4)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Peroxiredoxin 4 antibody is un-conjugated

Application: ELISA, Coating (Coat)

Clone: CPTC-PRDX4-2

Product Details anti-Peroxiredoxin 4 Antibody

Specificity: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human PRDX4 protein

Isotype: IgG2b kappa

Application Details

Application Notes:

Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: HepG2, HeLa and Jurkat cell lysates. Ovarian carcinoma tissue.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for Peroxiredoxin 4

Target: Peroxiredoxin 4 (PRDX4)

Alternative Name: PRDX4

Background: Antioxidant enzyme AOE372, EC 1.11.1.15, Thioredoxin dependent peroxide reductase A0372, TRANK,Peroxiredoxin 4 (Prognostic Marker for Lung SqCC)
Cellular localisation: Cytoplasm. Secreted.

Molecular Weight: 27kDa

Gene ID: 10549, 83383

UniProt: Q13162