RNLS antibody (AA 34-235)
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- Target See all RNLS Antibodies
- RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))
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Binding Specificity
- AA 34-235
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This RNLS antibody is un-conjugated
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Application
- ELISA, Coating (Coat)
- Specificity
- Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human RNLS protein fragment (around aa 34-235) (exact sequence is proprietary)
- Clone
- RNLS-1940
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product RNLS Primary Antibody
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- Application Notes
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Known_Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: 293T cells. Heart or Kidney.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))
- Alternative Name
- RNLS (RNLS Products)
- Synonyms
- zgc:92286 antibody, C10orf59 antibody, RENALASE antibody, 6530404N21Rik antibody, AI452315 antibody, AW060440 antibody, RGD1309804 antibody, renalase, FAD dependent amine oxidase antibody, renalase, FAD-dependent amine oxidase antibody, RNLS antibody, rnls antibody, Rnls antibody
- Background
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Chromosome 10 open reading frame 59, MAO C, MAO-C, Monoamine oxidase-C, Renalase, Renalase FAD dependent amine oxidase, RNLS,Renalase (Renal Cell Marker)
Cellular localisation: Secreted - Molecular Weight
- 38kDa
- Gene ID
- 55328, 149849
- UniProt
- Q5VYX0
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