RNLS antibody (AA 34-235)

Catalog No. ABIN6938322

The Mouse Monoclonal anti-RNLS antibody is suitable to detect RNLS in samples from Human. It has been validated for ELISA.

Quick Overview for RNLS antibody (AA 34-235) (ABIN6938322)

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RNLS antibody is un-conjugated

Application: ELISA

Clone: RNLS-1940

Product Details anti-RNLS Antibody

Binding Specificity: AA 34-235

Purpose: Renalase (Renal Cell Marker) Antibody

Specificity: Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human RNLS protein fragment (around aa 34-235) (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes:

Known_Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: 293T cells. Heart or Kidney.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for RNLS

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Alternative Name: RNLS

Background:

Chromosome 10 open reading frame 59, MAO C, MAO-C, Monoamine oxidase-C, Renalase, Renalase FAD dependent amine oxidase, RNLS

293T cells. Heart or Kidney.

Molecular Weight: 38kDa

Gene ID: 55328, 149849

UniProt: Q5VYX0