SERBP1 antibody (AA 3-139)

Catalog No. ABIN6938368

Product Details anti-SERBP1 Antibody

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Binding Specificity: AA 3-139

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SERBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-i± and may be involved in chromatin remodeling. It also interacts with PGRMC1 and participates in the transduction of Progesterone’s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human SERBP1 protein (around aa3-139) (exact sequence is proprietary)

Clone: SERBP1-3491

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: K562 or PC3 cells. Human kidney or bladder tissue (IHC).

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for SERBP1

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Alternative Name: SERBP1 (SERBP1 Products)

Synonyms: CHD3IP antibody, HABP4L antibody, PAI-RBP1 antibody, PAIRBP1 antibody, 1200009K13Rik antibody, 9330147J08Rik antibody, AL022786 antibody, Pairbp1 antibody, Pai-Rbp1 antibody, Rda288 antibody, cgi-55 antibody, chd3ip antibody, habp4l antibody, pai-rbp1 antibody, pairbp1 antibody, rda288 antibody, hm:zeh0245 antibody, serbp1 antibody, wu:fa12d05 antibody, wu:fb36e07 antibody, wu:fc16f12 antibody, wu:fj13e12 antibody, zgc:55489 antibody, SERPINE1 mRNA binding protein 1 antibody, serpine1 mRNA binding protein 1 antibody, Serpine1 mRNA binding protein 1 antibody, SERPINE1 mRNA binding protein 1 L homeolog antibody, SERPINE1 mRNA binding protein 1a antibody, SERBP1 antibody, Serbp1 antibody, serbp1.L antibody, serbp1a antibody

Background: CGI 55, CHD3IP, Chromodomain helicase DNA binding protein 3 interacting protein, HABP4L, PAI1 RNA-binding protein 1, PAIRBP1, Plasminogen activator inhibitor 1 RNA binding protein, SERPINE1 mRNA binding protein 1,SERBP1 / PAI-RBP1
Cellular localisation: Cytoplasm and nucleus. Also found in perinuclear regions.

Molecular Weight: 60kDa

Gene ID: 26135, 530412

UniProt: Q8NC51