SERBP1 antibody (AA 3-139)
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- Target See all SERBP1 Antibodies
- SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))
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Binding Specificity
- AA 3-139
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This SERBP1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-i± and may be involved in chromatin remodeling. It also interacts with PGRMC1 and participates in the transduction of Progesterone s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.
- Cross-Reactivity (Details)
- Human. Others not tested.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment of human SERBP1 protein (around aa3-139) (exact sequence is proprietary)
- Clone
- SERBP1-3496
- Isotype
- IgG2c kappa
- Top Product
- Discover our top product SERBP1 Primary Antibody
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- Application Notes
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Known_Application: Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: K562 or PC3 cells. Human kidney or bladder tissue (IHC).
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))
- Alternative Name
- SERBP1 (SERBP1 Products)
- Synonyms
- CHD3IP antibody, HABP4L antibody, PAI-RBP1 antibody, PAIRBP1 antibody, 1200009K13Rik antibody, 9330147J08Rik antibody, AL022786 antibody, Pairbp1 antibody, Pai-Rbp1 antibody, Rda288 antibody, cgi-55 antibody, chd3ip antibody, habp4l antibody, pai-rbp1 antibody, pairbp1 antibody, rda288 antibody, hm:zeh0245 antibody, serbp1 antibody, wu:fa12d05 antibody, wu:fb36e07 antibody, wu:fc16f12 antibody, wu:fj13e12 antibody, zgc:55489 antibody, SERPINE1 mRNA binding protein 1 antibody, serpine1 mRNA binding protein 1 antibody, Serpine1 mRNA binding protein 1 antibody, SERPINE1 mRNA binding protein 1 L homeolog antibody, SERPINE1 mRNA binding protein 1a antibody, SERBP1 antibody, Serbp1 antibody, serbp1.L antibody, serbp1a antibody
- Background
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CGI 55, CHD3IP, Chromodomain helicase DNA binding protein 3 interacting protein, HABP4L, PAI1 RNA-binding protein 1, PAIRBP1, Plasminogen activator inhibitor 1 RNA binding protein, SERPINE1 mRNA binding protein 1,SERBP1 / PAI-RBP1
Cellular localisation: Cytoplasm and nucleus. Also found in perinuclear regions. - Molecular Weight
- 60kDa
- Gene ID
- 26135, 530412
- UniProt
- Q8NC51
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