SHBG antibody

Catalog No. ABIN6938382

Product Details anti-SHBG Antibody

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SHBG antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: Recognizes a protein of 45 kDa, identified as SHBG. It functions as an androgen transport protein, but may also be involved in receptor-mediated processes. Each dimer binds one molecule of steroid. It is specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human SHBG protein

Clone: SPM605

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: Liver, Placenta or Testis.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for SHBG

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Alternative Name: SHBG (SHBG Products)

Synonyms: ABP antibody, SBP antibody, TEBG antibody, Abpa antibody, shbgl antibody, wu:fb66h07 antibody, wu:fd55b08 antibody, zgc:123063 antibody, shbg antibody, sex hormone binding globulin antibody, sex hormone-binding globulin antibody, sex hormone binding globulin L homeolog antibody, SHBG antibody, Shbg antibody, shbg antibody, shbg.L antibody

Background: Androgen binding protein (ABP), Sex hormone-binding globulin (SHBG), Sex steroid binding protein (SBP), Sex steroid-binding protein, Testis-specific androgen-binding protein, Testosterone binding beta globulin, Testosterone-Estradiol-Binding Globulin (TEBG),Sex Hormone Binding Globulin (SHBG)
Cellular localisation: Cytoplasmic & Extracellular (Secreted)

Molecular Weight: 45kDa

Gene ID: 6462, 632235

UniProt: P04278

Pathways: Hormone Transport