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Recombinant VTCN1 antibody

This anti-VTCN1 antibody is a Rabbit Monoclonal antibody detecting VTCN1 in ELISA, FACS, IF, Coat and IHC (f). Suitable for Human.
Catalog No. ABIN6938767

Quick Overview for Recombinant VTCN1 antibody (ABIN6938767)

Target

See all VTCN1 Antibodies
VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Antibody Type

Recombinant Antibody

Reactivity

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Human

Host

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Rabbit

Clonality

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Monoclonal

Conjugate

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This VTCN1 antibody is un-conjugated

Application

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ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone

B7H4-2652R
  • Specificity

    T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

    Cross-Reactivity (Details)

    Human.

    Purification

    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

    Immunogen

    A recombinant fragment of human B7-H4 protein (exact sequence is proprietary)

    Isotype

    IgG
  • Application Notes

    Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Flow Cytometry (1-2 μg/million cells in 0.1ml), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa, SKBr-3 or MCF-7 cells. Human ovary, pancreas, placenta or spleen.

    Restrictions

    For Research Use only
  • Concentration

    1.0 mg/mL

    Buffer

    Prepared in 10 mM PBS, WITHOUT BSA and Azide.

    Preservative

    Azide free

    Storage

    -20 °C,-80 °C

    Storage Comment

    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

    Expiry Date

    24 months
  • Target

    VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

    Alternative Name

    VTCN1

    Background

    B7 family member, H4, B7 homolog 4, B7 superfamily member 1, B7-H4, B7S1, Immune costimulatory protein B7-H4, T-cell costimulatory molecule B7x, V-set domain-containing T-cell activation inhibitor 1, VCTN1,B7-H4 (Immuno-Inhibitory Protein)
    Cellular localisation: Cell Surface & Cytoplasmic

    Molecular Weight

    35kDa

    Gene ID

    79679, 546434

    UniProt

    Q7Z7D3
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