BTLA antibody

Catalog No. ABIN6939222

This Mouse Monoclonal antibody specifically detects BTLA in ELISA and Coat. It exhibits reactivity toward Human.

Quick Overview for BTLA antibody (ABIN6939222)

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BTLA antibody is un-conjugated

Application: ELISA, Coating (Coat)

Clone: BTLA-1528

Product Details anti-BTLA Antibody

Purification: Purified by Protein A/G

Immunogen: Recombinant full-length human BTLA protein

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: Human lymph node or MDAMB468 xenograft.

Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Alternative Name: BTLA

Background: B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.

Molecular Weight: 33kDa

Gene ID: 151888

Pathways: Cancer Immune Checkpoints