BTLA antibody

Catalog No. ABIN7505891

Product Details anti-BTLA Antibody

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Reactivity: Human, Non-Human Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This BTLA antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purpose: Anti-Hu CD272 Purified

Specificity: The mouse monoclonal antibody MIH26 recognizes an extracellular epitope of CD272, a transmembrane glycoprotein serving as a negative regulator of the activation in various leukocyte types.

Purification: Purified by protein-A affinity chromatography.

Immunogen: cells transfected with human CD272

Clone: MIH26

Isotype: IgG2a kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 2-5 μg/mL.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Alternative Name: CD272 (BTLA Products)

Synonyms: BTLA antibody, BTLA1 antibody, CD272 antibody, A630002H24 antibody, B and T lymphocyte associated antibody, BTLA antibody, Btla antibody

Background: B and T lymphocyte associated,CD272, a type I transmembrane glycoprotein, contains in its intracellular domain two ITIM sequences, which are upon CD272 triggering phosphorylated and recruit SHP phosphatases to attenuate cell activation. CD272 is expressed on B and T lymphocytes, NK cells, dendritic cells, and macrophages, and its ligand is CD270. Defects in CD272-CD270 inhibitory mechanism lead to autoimmune diseases. Overexpression of CD272 is a marker of tolerant T cells.,BTLA1

Gene ID: 151888

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints