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FCGR3A antibody

FCGR3A Reactivity: Human FACS, IF, Func Host: Mouse Monoclonal HuNK2 unconjugated
Catalog No. ABIN6939377
  • Target See all FCGR3A Antibodies
    FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
    Reactivity
    • 48
    • 10
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 49
    • 11
    Mouse
    Clonality
    • 47
    • 12
    • 1
    Monoclonal
    Conjugate
    • 27
    • 11
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FCGR3A antibody is un-conjugated
    Application
    • 41
    • 28
    • 16
    • 7
    • 7
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)
    Specificity
    It recognizes CD16 (FcgammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcgammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcgammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
    Purification
    Purified by Protein A/G
    Immunogen
    Human peripheral blood lymphocytes from a NK-leukemia patient.
    Clone
    HuNK2
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product FCGR3A Primary Antibody
  • Application Notes

    Positive Control: K-562 or U-937 cells. Lymph nodes and tonsils.

    Known Application: Functional Studies (Order Ab without BSA & Azide), Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
    Alternative Name
    FCGR3A (FCGR3A Products)
    Synonyms
    CD16 antibody, CD16A antibody, FCG3 antibody, FCGR3 antibody, FCGRIII antibody, FCR-10 antibody, FCRIII antibody, FCRIIIA antibody, IGFR3 antibody, Fcgr4 antibody, Fc fragment of IgG receptor IIIa antibody, FCGR3A antibody, Fcgr3a antibody
    Molecular Weight
    50-80kDa
    Gene ID
    2214
    UniProt
    P08637
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