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MAGEA1 antibody

MAGEA1 Reactivity: Human, Rat, Dog IHC, StM Host: Mouse Monoclonal MA454 unconjugated
Catalog No. ABIN6940000
  • Target See all MAGEA1 Antibodies
    MAGEA1 (Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) (MAGEA1))
    Reactivity
    • 60
    • 28
    • 12
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Dog
    Host
    • 42
    • 18
    Mouse
    Clonality
    • 42
    • 18
    Monoclonal
    Conjugate
    • 31
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAGEA1 antibody is un-conjugated
    Application
    • 45
    • 24
    • 23
    • 17
    • 13
    • 13
    • 13
    • 10
    • 9
    • 4
    • 4
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificity
    Recognizes a protein of 42-46 kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human MAGE-A1 protein
    Clone
    MA454
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product MAGEA1 Primary Antibody
  • Application Notes

    Positive Control: Melanoma cell lines. Melanomas or testicular carcinomas.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    MAGEA1 (Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) (MAGEA1))
    Alternative Name
    MAGEA1 (MAGEA1 Products)
    Synonyms
    CT1.1 antibody, MAGE1 antibody, Mage-a1 antibody, MAGE family member A1 antibody, melanoma antigen, family A, 1 antibody, MAGEA1 antibody, Magea1 antibody
    Molecular Weight
    42-46kDa
    Gene ID
    4100
    UniProt
    P43355
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