MUC4 antibody (AA 1730-1864)

Catalog No. ABIN6940126

This anti-MUC4 antibody is a Mouse Monoclonal antibody detecting MUC4 in IHC and StM. Suitable for Human.

Quick Overview for MUC4 antibody (AA 1730-1864) (ABIN6940126)

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MUC4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: MUC4-3105

Product Details anti-MUC4 Antibody

Binding Specificity: AA 1730-1864

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: Stomach, Colon or esophagus.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for MUC4

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Alternative Name: MUC4

Background: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.

Molecular Weight: 235kDa

Gene ID: 4585

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity