Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

NFE2L1 antibody

NFE2L1 Reactivity: Human WB, IHC, StM Host: Mouse Monoclonal NRF1-2609 unconjugated
Catalog No. ABIN6940224
  • Target See all NFE2L1 Antibodies
    NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
    Reactivity
    • 42
    • 19
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 38
    • 4
    Mouse
    Clonality
    • 39
    • 3
    Monoclonal
    Conjugate
    • 22
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NFE2L1 antibody is un-conjugated
    Application
    • 30
    • 21
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human NRF1 protein
    Clone
    NRF1-2609
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product NFE2L1 Primary Antibody
  • Application Notes

    Positive Control: Ubiquitous expression, strongest in skeletal muscle.

    Known Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
    Alternative Name
    NFE2L1 (NFE2L1 Products)
    Synonyms
    LCR-F1 antibody, NRF1 antibody, TCF11 antibody, AA408798 antibody, AW212678 antibody, Lcrf1 antibody, TCF-11 antibody, nfe2l1 antibody, nuclear factor, erythroid 2 like 1 antibody, nuclear factor, erythroid derived 2,-like 1 antibody, nuclear factor, erythroid 2-like 1 antibody, nuclear factor, erythroid 2 like 1 S homeolog antibody, nuclear factor, erythroid 2-like 1a antibody, NFE2L1 antibody, Nfe2l1 antibody, nfe2l1.S antibody, nfe2l1a antibody
    Background
    The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes.
    Molecular Weight
    30kDa (bZIP region), 65-120kDa (glycosylated)
    Gene ID
    4899
    UniProt
    Q16656
You are here:
Support