PMEPA1 antibody

Catalog No. ABIN6940418

The Mouse Monoclonal anti-PMEPA1 antibody is suitable to detect PMEPA1 in samples from Human. It has been validated for IHC.

Quick Overview for PMEPA1 antibody (ABIN6940418)

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PMEPA1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PMEPA1-2697

Product Details anti-PMEPA1 Antibody

Purpose: PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein) Antibody

Specificity: PMEPA1 (prostate transmembrane protein, androgen induced 1 is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1 interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of PMEPA1 is observed in prostate tumors, suggesting that PMEPA1 may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human PMEPA1 protein

Isotype: IgG, kappa

Application Details

Application Notes:

Positive Control: SKBR-3 cells. Prostate, Breast or Renal Cell Carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for PMEPA1

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Alternative Name: PMEPA1

Background:

PMEPA, PMEPA1, Prostate transmembrane protein, androgen induced 1, Solid tumor-associated 1 protein, STAG1, TMEPAI, Transmembrane prostate androgen-induced protein, Transmembrane, prostate androgen induced RNA

Human prostate, breast or renal cell carcinoma tissue (IHC). SKBR-3 cells.

Molecular Weight: 32kDa

Gene ID: 56937, 517155

UniProt: Q969W9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway