BCL10 antibody

Catalog No. ABIN6942238

The Rabbit Monoclonal anti-BCL10 antibody is suitable to detect BCL10 in samples from Human and Mouse. It has been validated for IHC (p) and IF (cc).

Quick Overview for BCL10 antibody (ABIN6942238)

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BCL10 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 3F4

Product Details anti-BCL10 Antibody

Purification: Purified by Protein A.

Immunogen: Recombinant human Bcl10 protein, around C-terminal 200aa.

Isotype: IgG

Application Details

Application Notes: IHC-P(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Alternative Name: Bcl10

Background:

Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).

Synonyms: CLAP, mE10, CIPER, IMD37, c-E10, CARMEN, B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3/ICH-1 prodomain homologous E10-like regulator, Cellular homolog of vCARMEN, cCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, BCL10

Gene ID: 8915

UniProt: O95999

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins